Table 2 Differentially methylated CpG sites and their associations with death in the discovery cohort and validation cohort
From: DNA methylation predicts adverse outcomes of coronary artery disease
Probes | Discovery cohort | Validation cohort | CHR | BP | UCSC_RefGene | UCSC_Refgene_Group | ||
|---|---|---|---|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |||||
cg05773425 | 1.48(1.3-1.67) | 6.73E-10 | 1.77(1.17-2.69) | 7.04E-03 | 1 | 16644480 | FBXO42 | 5’UTR |
cg04893281 | 1.52(1.33-1.75) | 9.68E-10 | 1.69(1.05-2.72) | 2.95E-02 | 10 | 97732939 | ENTPD1-AS1 | Body |
cg20005350 | 1.47(1.29-1.67) | 5.67E-09 | 1.7(1.08-2.68) | 2.13E-02 | 5 | 111478628 | EPB41L4A | NA |
cg22282161 | 1.48(1.29-1.69) | 1.62E-08 | 1.75(1.09-2.82) | 2.12E-02 | 7 | 21590890 | DNAH11 | Body |
cg16500036 | 1.44(1.26-1.64) | 4.17E-08 | 1.63(1.09-2.44) | 1.81E-02 | 7 | 68983906 | NA | |
cg12234768 | 1.45(1.27-1.65) | 4.37E-08 | 1.65(1.03-2.65) | 3.74E-02 | 2 | 88862824 | LOC101928371 | Body;Body |
cg27554156 | 1.45(1.26-1.66) | 1.19E-07 | 2.17(1.24-3.79) | 6.91E-03 | 12 | 13248725 | GSG1 | Body; TSS200 |
cg24348980 | 1.43(1.25-1.64) | 1.26E-07 | 2.48(1.51-4.06) | 3.06E-04 | 1 | 232073393 | DISC1-IT1;DISC1 | |
cg19526450 | 1.42(1.24-1.62) | 2.50E-07 | 1.65(1.04-2.59) | 3.22E-02 | 5 | 142254301 | ARHGAP26 | Body;Body |
cg01068906 | 1.43(1.24-1.64) | 4.12E-07 | 1.68(1.04-2.72) | 3.41E-02 | 16 | 50745944 | NOD2 | Body |
cg21163665 | 1.43(1.24-1.64) | 5.02E-07 | 1.82(1.11-3) | 1.83E-02 | 12 | 124657078 | ZNF664-FAM101A | 5’UTR |
cg08421448 | 1.42(1.24-1.63) | 5.46E-07 | 1.69(1.07-2.66) | 2.33E-02 | 16 | 31106703 | VKORC1 | TSS1500;TSS1500 |
cg11237636 | 1.38(1.21-1.56) | 6.05E-07 | 1.89(1.2-2.97) | 6.00E-03 | 10 | 126380541 | FAM53B | Body |
cg09481056 | 1.41(1.23-1.61) | 6.77E-07 | 1.54(1.01-2.34) | 4.56E-02 | 16 | 2339260 | ABCA3 | Body |
cg13165240 | 1.38(1.22-1.57) | 8.44E-07 | 1.66(1.11-2.49) | 1.38E-02 | 17 | 3715743 | C17orf85 | 3’UTR;3’UTR |
cg08538581 | 1.42(1.24-1.64) | 8.95E-07 | 1.66(1.06-2.59) | 2.72E-02 | 1 | 162500634 | UHMK1 | NA |
cg04036920 | 1.36(1.2-1.53) | 9.25E-07 | 1.52(1.07-2.16) | 1.86E-02 | 11 | 33562503 | C11orf41 | TSS1500 |
cg11058932 | 1.42(1.23-1.63) | 1.37E-06 | 2.13(1.36-3.35) | 1.04E-03 | 7 | 130372167 | TSGA13 | TSS1500 |
cg04213647 | 1.33(1.18-1.49) | 1.57E-06 | 1.78(1.2-2.63) | 4.29E-03 | 13 | 99499944 | DOCK9 | Body;Body |
cg13711762 | 1.38(1.21-1.58) | 1.58E-06 | 1.73(1.14-2.65) | 1.09E-02 | 10 | 76598375 | KAT6B | 5’UTR;5’UTR;5’UTR |
cg21223135 | 1.41(1.22-1.63) | 2.69E-06 | 1.7(1.01-2.87) | 4.65E-02 | 6 | 149320810 | UST | Body |
cg04944536 | 1.35(1.19-1.54) | 2.95E-06 | 1.76(1.19-2.6) | 4.52E-03 | 12 | 116756890 | NA | |
cg09663430 | 1.39(1.21-1.59) | 3.11E-06 | 1.78(1.07-2.94) | 2.59E-02 | 22 | 18251942 | BID | 5’UTR |
cg19599611 | 1.39(1.21-1.6) | 3.32E-06 | 1.6(1.1-2.32) | 1.40E-02 | 15 | 35148637 | AQR | 3’UTR |
cg02453046 | 1.34(1.19-1.52) | 3.59E-06 | 2.06(1.26-3.37) | 3.82E-03 | 21 | 17210173 | USP25 | Body;Body;Body |
cg15685198 | 1.41(1.22-1.63) | 4.29E-06 | 1.87(1.22-2.86) | 4.13E-03 | 2 | 135163836 | MGAT5 | Body |
cg02235918 | 1.34(1.18-1.51) | 4.34E-06 | 1.56(1.04-2.36) | 3.35E-02 | 6 | 72043561 | NA | |
cg13673960 | 1.33(1.18-1.51) | 4.67E-06 | 1.53(1.03-2.27) | 3.65E-02 | 4 | 1742301 | TACC3 | Body |
cg10272433 | 0.81(0.74-0.89) | 4.93E-06 | 0.79(0.62-0.99) | 4.32E-02 | 7 | 100732423 | TRIM56 | Body |
cg14932313 | 1.34(1.18-1.51) | 5.42E-06 | 1.66(1.1-2.51) | 1.54E-02 | 14 | 25043420 | CTSG | Body |
cg09479650 | 1.36(1.19-1.55) | 5.53E-06 | 1.64(1.1-2.44) | 1.48E-02 | 16 | 85578516 | NA | |
cg08960917 | 1.37(1.2-1.57) | 5.82E-06 | 1.6(1.01-2.52) | 4.32E-02 | 9 | 127114588 | NEK6;LOC100129034 | |
cg05673431 | 0.75(0.66-0.85) | 6.10E-06 | 0.39(0.24-0.65) | 3.11E-04 | 17 | 25871504 | KSR1 | 5’UTR |
cg00013899 | 1.37(1.19-1.57) | 6.17E-06 | 1.73(1.05-2.85) | 3.22E-02 | 1 | 64992433 | CACHD1 | Body |
cg09007354 | 1.36(1.19-1.55) | 6.54E-06 | 1.54(1.02-2.32) | 3.79E-02 | 1 | 54100163 | GLIS1 | 5’UTR |
cg25114611 | 0.73(0.64-0.84) | 6.98E-06 | 0.65(0.45-0.94) | 2.10E-02 | 6 | 35696870 | FKBP5;LOC285847 | TSS1500;Body |
cg19782190 | 1.36(1.19-1.56) | 7.13E-06 | 1.6(1-2.55) | 4.77E-02 | 14 | 103487004 | CDC42BPB | Body |
cg12992827 | 0.75(0.66-0.85) | 7.58E-06 | 0.62(0.4-0.96) | 3.10E-02 | 3 | 101901234 | ZPLD1 | NA |
cg25563198 | 0.73(0.64-0.84) | 8.00E-06 | 0.61(0.44-0.87) | 5.33E-03 | 6 | 35696726 | FKBP5;LOC285847 | TSS1500;Body |
cg13518537 | 1.34(1.18-1.53) | 8.37E-06 | 1.42(1.02-1.99) | 3.95E-02 | 8 | 28618150 | EXTL3 | NA |
cg24246360 | 1.38(1.2-1.59) | 8.72E-06 | 1.65(1.05-2.58) | 2.82E-02 | 6 | 82954226 | IBTK | 5’UTR |
cg00716819 | 0.73(0.64-0.84) | 8.72E-06 | 0.57(0.37-0.89) | 1.29E-02 | 10 | 71882625 | AIFM2 | Body;Body |
cg17633019 | 1.38(1.2-1.58) | 8.82E-06 | 1.6(1-2.54) | 4.87E-02 | 7 | 143015959 | CLCN1 | Body;Body |
cg23064873 | 1.33(1.17-1.5) | 9.31E-06 | 1.67(1.11-2.51) | 1.37E-02 | 8 | 37457573 | NA | |
cg27430693 | 1.31(1.16-1.48) | 9.36E-06 | 1.57(1.03-2.4) | 3.48E-02 | 12 | 94208276 | CRADD | Body |
cg13619623 | 1.39(1.2-1.6) | 1.04E-05 | 1.82(1.12-2.97) | 1.54E-02 | 7 | 33637324 | BBS9 | Body; |
cg01561259 | 1.36(1.19-1.56) | 1.04E-05 | 1.68(1.08-2.62) | 2.18E-02 | 17 | 78560781 | RPTOR | Body;Body |
cg22416486 | 1.39(1.2-1.61) | 1.05E-05 | 1.69(1.07-2.67) | 2.34E-02 | 15 | 79704442 | TMED3 | NA |
cg27380880 | 1.37(1.19-1.58) | 1.23E-05 | 2.43(1.33-4.41) | 3.66E-03 | 12 | 65022110 | RASSF3 | Body;Body |
cg15981626 | 0.75(0.66-0.85) | 1.37E-05 | 0.6(0.39-0.91) | 1.56E-02 | 3 | 71355303 | FOXP1 | TSS1500;5’UTR |
cg06872019 | 1.33(1.17-1.51) | 1.43E-05 | 1.65(1.04-2.62) | 3.40E-02 | 13 | 31588778 | LINC01066 | NA |
cg10079576 | 1.34(1.17-1.53) | 1.64E-05 | 1.83(1.19-2.81) | 6.15E-03 | 6 | 135328150 | HBS1L | Body |
cg09894169 | 0.75(0.66-0.86) | 1.64E-05 | 0.54(0.34-0.88) | 1.34E-02 | 1 | 61423884 | NFIA-AS2 | Body |
cg21371012 | 1.35(1.18-1.55) | 1.67E-05 | 1.8(1.17-2.76) | 7.28E-03 | 8 | 119269219 | SAMD12 | Body |
cg17953136 | 1.31(1.16-1.49) | 1.74E-05 | 1.84(1.23-2.76) | 3.12E-03 | 2 | 20232577 | LAPTM4A | 3’UTR |
cg07877229 | 1.46(1.23-1.74) | 1.79E-05 | 1.8(1.1-2.93) | 1.85E-02 | 7 | 142554307 | EPHB6 | 5’UTR |
cg12568458 | 1.36(1.18-1.56) | 1.84E-05 | 1.55(1.02-2.36) | 3.99E-02 | 16 | 19589790 | C16orf62 | Body |
cg17635409 | 1.36(1.18-1.57) | 1.86E-05 | 1.78(1.17-2.72) | 7.04E-03 | 16 | 66836220 | CCDC79 | TSS1500 |
cg26869211 | 1.32(1.16-1.5) | 1.87E-05 | 1.88(1.18-3.01) | 8.08E-03 | 17 | 58309224 | SCARNA20; USP32 | TSS1500;Body |
cg05459163 | 1.33(1.17-1.51) | 1.88E-05 | 1.78(1.13-2.82) | 1.33E-02 | 14 | 92411904 | FBLN5 | Body |
cg12828354 | 1.33(1.17-1.51) | 1.94E-05 | 2.13(1.36-3.35) | 9.40E-04 | 5 | 149466715 | CSF1R | TSS1500;5’UTR |
cg06258764 | 0.76(0.67-0.86) | 1.94E-05 | 0.59(0.42-0.83) | 2.56E-03 | 10 | 73510169 | C10orf54; CDH23 | 3’UTR;Body |
cg22995183 | 1.33(1.17-1.51) | 2.02E-05 | 1.7(1.08-2.67) | 2.12E-02 | 16 | 14293184 | MKL2 | Body;Body |
cg13125822 | 0.71(0.61-0.83) | 2.04E-05 | 0.57(0.35-0.92) | 2.00E-02 | 10 | 121061302 | GRK5 | Body |
cg02453588 | 0.75(0.65-0.85) | 2.10E-05 | 0.78(0.65-0.93) | 6.71E-03 | 9 | 110331783 | NA | NA |
cg27221998 | 1.37(1.19-1.59) | 2.19E-05 | 1.62(1.01-2.61) | 4.75E-02 | 3 | 186002153 | DGKG | Body; |
cg10985150 | 1.38(1.19-1.6) | 2.20E-05 | 2.83(1.6-4.99) | 3.34E-04 | 6 | 150989765 | PLEKHG1 | 5’UTR |
cg00442390 | 0.75(0.66-0.86) | 2.22E-05 | 0.47(0.3-0.73) | 9.00E-04 | 6 | 56584334 | RNU6-71P; DST | Body |
cg00748072 | 1.33(1.16-1.51) | 2.25E-05 | 1.53(1.01-2.32) | 4.33E-02 | 2 | 174862824 | NA | NA |
cg18600016 | 1.35(1.17-1.55) | 2.27E-05 | 1.85(1.1-3.1) | 1.98E-02 | 8 | 95772595 | DPY19L4 | Body |
