Fig. 4: Cryo-EM structure of the importin β:Ran-GTP complex.
From: Ran modulates allosteric crosstalk between importin β surfaces
A Representative 2D class averages (top) and the 3D structure of the importin β:Ran-GTP complex (bottom). Importin β is colored blue, while Ran-GTP is colored magenta. The final 3.34 Å cryo-EM density (gray) for Ran-GTP is overlaid with the refined model. B A schematic diagram illustrates the contacts between importin β and Ran-GTP within a distance of 4.5 Å. C The superimposition of Kap95p:Ran-GTP (PDB: 2BKU) with the importin β:Ran-GTP solved in this study is represented as beads-on-a-string. Each bead represents a HEAT repeat, while Ran-GTP is depicted in ribbon representation. Kap95p is colored yellow, and importin β is colored blue.
