Fig. 3: PLUM loss accelerates coordinated activation of naïve pluripotency markers. | Nature Communications

Fig. 3: PLUM loss accelerates coordinated activation of naïve pluripotency markers.

From: Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development

Fig. 3

a Principal component analysis (PCA) of time-course transcriptomes (day 0–10) from WT and PLUM KO cells compared with rESCs. b Time-series clustering of differentially expressed genes in WT and KO cells. c Gene ontology (GO) enrichment analysis of cluster 2 and cluster 6 genes in KO cells. d Cluster assignments of naïve pluripotency marker genes in WT and KO cells. e Heatmap showing the expression dynamics of representative pluripotency markers during PNT.

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