Table 1 Susceptibility of influenza A(H1N1)pdm09 viruses with HA and/or NA mutations to NAIs assessed by enzymatic assay
Influenza viruses | Mutations | Oseltamivir | Zanamivir | |||
|---|---|---|---|---|---|---|
HA | NA | Mean IC50 ± SD (nM) | Fold change | Mean IC50 ± SD (nM) | Fold change | |
A/California/07/2009 (H1N1) | WT | WT | 0.23 ± 0.12 | 1 | 0.19 ± 0.07 | 1 |
K130N | – | 0.27 ± 0.17 | 1 | 0.17 ± 0.05 | 1 | |
K130E | – | 0.22 ± 0.05 | 1 | 0.21 ± 0.02 | 1 | |
– | N295S | 22.94 ± 3.45 | 100 | 0.45 ± 0.13 | 2 | |
K130N | N295S | 30.54 ± 1.42 | 133 | 0.44 ± 0.09 | 2 | |
A/Illinois/45/2019 (H1N1) | – | – | 0.13 ± 0.04 | 1 | 0.13 ± 0.02 | 1 |
A/Alabama/03/2020 (H1N1) | – | H275Y | 125.31 ± 22.15 | 545 | 0.19 ± 0.03 | 1 |
