Fig. 2: Single intrarectal challenge with 500 MID50 SHIV-325C or SHIV-SF162P3 but not 0.5 MID50 SHIV-SF162P3 resulted in productive infection in rhesus macaques. | Nature Communications

Fig. 2: Single intrarectal challenge with 500 MID50 SHIV-325C or SHIV-SF162P3 but not 0.5 MID50 SHIV-SF162P3 resulted in productive infection in rhesus macaques.

From: Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques

Fig. 2

Macaques received a single intrarectal challenge with SHIV-325C or SHIV-SF162P3, and viral loads were monitored for 70–84 days. Median values are shown in red. a Experimental design. b Animals (n = 3) intrarectally challenged with 500 MID50 of SHIV-325C were productively infected. c Animals (n = 4) intrarectally challenged with 500 MID50 of SHIV-SF162P3 were productively infected. d Animals (n = 4) intrarectally challenged with 0.5 MID50 of SHIV-SF162P3 were not productively infected. Source data are provided as a Source Data file.

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