Fig. 3: Synthesis of chiral tricyclo[5.2.1.04,8]decadienes. | Nature Communications

Fig. 3: Synthesis of chiral tricyclo[5.2.1.04,8]decadienes.

From: Catalytic asymmetric tandem Heck/Sonogashira reaction enabling access to versatile chiral bridged ring scaffolds

Fig. 3

a Au-catalyzed intramolecular alkene-alkyne coupling reactions. b Cycloisomerizations of 3aa and further transformations. aAuPPh3Cl, AgSbF6, THF. b24 h. cMeMgBr, THF. dNIS, DCM. e4-MeOC6H4B(OH)2, Pd(OAc)2, S-Phos, K3PO4, Toluene. fEthyl acrylate, Pd(OAc)2, PPh3, Et3N, DMF. gPhenylacetylene, Pd(PPh3)2Cl2, CuI, Et3N/Toluene = 1/3. hCO, Pd(OAc)2, DPPF, DIPEA, MeOH. iDCO2Na, Pd(PPh3)2Cl2, Et3N, DMF. jPhSeSePh, NFSI, THF.

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