Fig. 4: Brain-targeting effects of liposomes in vivo. | Nature Communications

Fig. 4: Brain-targeting effects of liposomes in vivo.

From: Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain

Fig. 4

A Fluorescence imaging demonstrated the biodistribution of liposomes in mouse brain tissue; B Biodistribution analysis across major organs (brain, heart, liver, spleen, lungs, kidneys) showed predominant localization in the brain and spleen; C Statistical analysis of average fluorescence intensity and DiR in the mouse brain; D Quantification of TDP-43 levels in mouse brain tissue. E TF/PS/TDP-43-IN-1 showed effective targeting to astrocytes (GFAP-positive) and microglia (CD86-positive) in the brains of CCI mice. Scale bar = 25 μm. F Nanoparticle uptake tracking via fluorescence imaging revealed robust cellular absorption, with arrows indicating perinuclear accumulation of nanoparticles. Data conforming to a normal distribution are presented as mean ± standard deviation (SD). Comparisons between two groups were conducted using independent sample t-tests. For comparisons among multiple groups, one-way analysis of variance (ANOVA) was used. * indicates p < 0.05 between groups: experimental animals, n = 6.

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