Fig. 5: Effects of prophylactic and therapeutic intrathecal administration of TF/PS/TDP-43-IN-1 on NP and neuroinflammation. | Nature Communications

Fig. 5: Effects of prophylactic and therapeutic intrathecal administration of TF/PS/TDP-43-IN-1 on NP and neuroinflammation.

From: Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain

Fig. 5

A Schematic diagram of the prophylactic injection experimental procedure (Created in BioRender. J, M. (2025) https://BioRender.com/j57dtiq); B Quantification of mechanical withdrawal thresholds and thermal latency following treatment, showing improvement in pain thresholds; C Assessment of cold allodynia latency, indicating effective reversal by liposomal treatment; D qRT-PCR detection of IL-6 and TNF-α mRNA expression in spinal cord tissues revealed reduced pro-inflammatory cytokine expression following treatment; E Schematic diagram of the therapeutic injection experimental procedure (Created in BioRender. J, M. (2025) https://BioRender.com/51wvmie); F Quantification of mechanical and thermal pain thresholds post-therapy, demonstrating significant analgesic effects of liposomes; G Rotarod test results showing improvement in coordination and endurance after treatment; H qRT-PCR analysis showing reduced spinal IL-6 and TNF-α mRNA expression levels following liposomal therapy: * indicates comparison with the sham group, # indicates comparison with the CCI group, & indicates comparison with the CCI + TDP-43-in group, p < 0.05. For other panels: * indicates p < 0.05 between groups: experimental animals, n = 6. Data conforming to a normal distribution are presented as mean ± standard deviation (SD). Comparisons between two groups were conducted using independent sample t-tests. For comparisons among multiple groups, one-way analysis of variance (ANOVA) was used.

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