Fig. 4: Substrate scope for (a) photocatalytic reactions of 3-(2-isocyanobenzyl)-indoles with phosphine oxides and (b) photocatalytic cyclizations of tryptamine-derived isocyanides with thiophenols. | Nature Communications

Fig. 4: Substrate scope for (a) photocatalytic reactions of 3-(2-isocyanobenzyl)-indoles with phosphine oxides and (b) photocatalytic cyclizations of tryptamine-derived isocyanides with thiophenols.

From: Straightforward construction of functionalized γ-lactams via conjugated-engineered covalent organic framework photocatalysed cascade reactions

Fig. 4: Substrate scope for (a) photocatalytic reactions of 3-(2-isocyanobenzyl)-indoles with phosphine oxides and (b) photocatalytic cyclizations of tryptamine-derived isocyanides with thiophenols.

a All reactions were carried out on a 0.3 mmol scale with 1.0 eq. isocyanides 4, 2.0 eq. phosphine oxides 2, 2 mol% NPy-DMTP-COF and 2.0 eq. Na2HPO4 in 4.0 mL CH3CN under irradiation of 420 nm blue LEDs with N2 protection at room temperature for 48–96 h. b All reactions were carried out on a 0.3 mmol scale with 1.0 eq. isocyanides 1, 2.0 eq. thiophenols 6, 2 mol% NPy-DMTP-COF and 2.0 eq. Na2HPO4 in 4.0 mL CH3CN under irradiation of 450 nm blue LEDs with N2 protection at room temperature for 48–96 h. Isolated yield.

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