Fig. 1: Atorvastatin binding to the open state. | Nature Communications

Fig. 1: Atorvastatin binding to the open state.

From: Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets

Fig. 1

A chemical structure of atorvastatin, indicating the various constituent moieties. B Density for the three atorvastatin molecules per RyR1 protomer, contoured at 5.5σ. The three molecules are shown in stick representation (red: oxygen; blue: nitrogen; light green: fluorine; yellow/green/magenta: carbon for ator1,ator2 and ator3, respectively). C Side-view (top panel) of the open RyR1 bound to atorvastatin, with one of the protomers highlighted in orange. The inset shows a top view (facing the SR lumen) of the transmembrane region. Transmembrane helices (S1–S6) are labeled, and the statins are shown in colored sticks (yellow, green, magenta). D Density for the 3 atorvastatin molecules in relation to neighboring protein density. The density map is shown at a cut-off of 5.5σ. E–G. details of the chemical environments of the three statin molecules in the open-state RyR1. Blue dashed lines represent polar contacts, including H-bonds (3.5 Å distance cut-off) and salt bridges (4 Å cut-off). Black dashed lines represent additional van der Waals interactions (4 Å distance cut-off).

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