Fig. 3: Single-nuclei RNA-seq data from patients included in the neoRHEA study. | Nature Communications

Fig. 3: Single-nuclei RNA-seq data from patients included in the neoRHEA study.

From: Palbociclib and endocrine therapy diminish adaptive anti-tumor immunity in early breast cancer: The NeoRHEA phase 2 study

Fig. 3

a UMAP representation of nuclei colored by cell type. Nuclei are colored according to the assigned cell type. b Copy number aberrations per nuclei; X-axis represents genomic regions from chromosome 1 to chromosome 22, while each row of the Y-axis represents a specific nucleus, colored bars denote the cell type label. Tumor cells display abundant copy number aberrations compared to other cell types. c Barplot of cell type proportions (Y-axis) per patient (X-axis). d Expression of marker genes of tumor cells and normal epithelial cells (ESR1, ANKRD30A, KRT19), stromal cells (PECAM1, FAP, ACTA2, CD68), and immune cells (MS4A1, PTPRC). Source data are deposited in GEO.

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