Fig. 2: Fine-scale population history in the MGBB.
From: Genetics and context for precision health in Greater Boston
a PCA representation of the genetic clusters in MGBB. Each dot represents a participant, with colors indicating distinct genetic clusters identified through graph-based clustering from genetic principal components (Methods). The numbers indicate cluster identification. The detailed cluster information will be found in Supplementary Table 3. b Population differentiation in MGBB revealed by ADMIXTURE analysis. The heatmap displays the proportions of ADMIXTURE components (K = 10) within each genetic cluster. The columns at the top of the heatmap represent the number of MGBB participants in each cluster. c Effective population size estimated using coalescent pattern in MGBB genetic clusters. The horizontal axis shows generations ago from the present. The vertical axis shows the effective population size. Black lines indicate estimates, and gray lines indicate 95% confidence interval. The numbers on the top of charts indicate genetic cluster. UKBB British and Irish are the estimates from self-reported White British and Irish in UKBB. PC principal component, 1KG 1000 genomes project, HGDP Human Genome Diversity Project, MGBB Mass General Brigham Biobank, UKBB UK Biobank.
