Fig. 8: Humoral and memory immune responses induced by BacOR-Fn-T+phiX174 oral vaccination. | Nature Communications

Fig. 8: Humoral and memory immune responses induced by BacOR-Fn-T+phiX174 oral vaccination.

From: Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays

Fig. 8: Humoral and memory immune responses induced by BacOR-Fn-T+phiX174 oral vaccination.

A Schematic of long-term immunity assessment. B, C TRP2- and OVA-specific serum IgG levels at different timepoints after three oral vaccinations detected by ELISA assay (n = 3 mice per group). D Flow cytometry plots of CD8+ memory T cells in spleens at day 50. E, F Quantification of effector (CD3+CD8+CD44+CD62−) (E) and central (CD3+CD8+CD44+CD62+) (F) memory T cells (n = 3 mice per group) in spleens at day 50. G Schematic and results of tumor rechallenge on day 50; metastatic nodules were quantified on day 65. Data are shown as mean ± SD; analyzed by one-way ANOVA with a Sidak’s multiple comparisons test. Source data are provided as a Source Data file.

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