Fig. 5: Fluctuational dynamics of the apo-state CeLGR homodimer. The centroid model is in the center column (colored as in Fig. 1) and extreme conformers 1 (blue) and 2 (pink) are in the columns at left and right, respectively. | Nature Communications

Fig. 5: Fluctuational dynamics of the apo-state CeLGR homodimer. The centroid model is in the center column (colored as in Fig. 1) and extreme conformers 1 (blue) and 2 (pink) are in the columns at left and right, respectively.

From: Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors

Fig. 5

a ECDs as viewed down the indicated screw axes with interprotomer rotations indicated. b TMDs as viewed into the membrane from extracellular side with TMs drawn as cylinders. The centroid model (center) is superimposed on the extreme conformers (1, left; 2, right) with excursion rotations indicated by directed arrows. Measures of expansion and contraction are given as distances between markers Cα 573 in protomer A and Cα 502 in protomer B. c Side views of the CeLGR homodimer as in Fig. 1b. The angles between the ECD axis indicator (Cα 55 and Cα 413) and the plane normal to the screw axis are given for each chain, and excursion rotations are indicated by directed arrows.

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