Fig. 2: Negative staining TEM images of RAD51 fibrils/oligomers in the presence and in the absence of Apt1. | Nature Communications

Fig. 2: Negative staining TEM images of RAD51 fibrils/oligomers in the presence and in the absence of Apt1.

From: Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality

Fig. 2: Negative staining TEM images of RAD51 fibrils/oligomers in the presence and in the absence of Apt1.

A RAD51 by itself, displaying the characteristic fibril structure. B RAD51 incubated with Apt1 at a molar ratio of 1:1, exhibiting similar supramolecular structures. C RAD51 incubated with Apt1 at a molar ratio of 1:6, revealing a significant reduction in the presence of long fibrils, accompanied by the formation of smaller oligomeric structures. D RAD51 incubated with Apt1 at a molar ratio of 1:12, resulting in the complete abrogation of fibrils. Experiments were performed in biological triplicate, and data were collected from eight images per experiment. Source data are provided as a Source Data file.

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