Fig. 3: Structural prediction of RAD51 fibrils/oligomers in the presence and absence of Apt1. | Nature Communications

Fig. 3: Structural prediction of RAD51 fibrils/oligomers in the presence and absence of Apt1.

From: Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality

Fig. 3

A RAD51 by itself (6 protomers), displaying the characteristic fibril structure. B One filament of RAD51 in complex with one Apt1 molecule, exhibiting a similar supramolecular structure with A. C One filament of RAD51 in complex with six Apt1 molecules, revealing a reorganization of the protofilament into a hexameric annular structure. D One filament of RAD51 in complex with 12 Apt1 molecules, resulting in the complete abrogation of the fibrils. In this latest case, two trimers are interacting with several copies of the aptamer. Each protein chain is shown in a different color using the cartoon-based representation (chain A in orange, B in magenta, C in cyan, D in pink, E in silver and F in green). Each aptamer copy is reported as a blue ribbon, with the sugar rings in yellow and the nucleobases in red.

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