Fig. 2: in vivo protein-DNA profiling by TaDa revealed WNT/Wingless signaling as a primary target of Simba1 and Simba2 in Drosophila NSCs. | Nature Communications

Fig. 2: in vivo protein-DNA profiling by TaDa revealed WNT/Wingless signaling as a primary target of Simba1 and Simba2 in Drosophila NSCs.

From: Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila

Fig. 2: in vivo protein-DNA profiling by TaDa revealed WNT/Wingless signaling as a primary target of Simba1 and Simba2 in Drosophila NSCs.

A Workflow of Simba1 and Simba2 Tada (DamID)-seq. B Venn diagram of Simba1 and Simba2 target genes (2 replicates each) from DamID-seq. C Dot plot of KEGG pathway enrichment results on Simba1 target genes. D Dot plot of KEGG pathway enrichment results on Simba2 target genes. For KEGG enrichment analysis in (C, D), a one-sided hypergeometric test was used to assess enrichment, with Benjamini–Hochberg correction applied for multiple comparisons.

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