Fig. 7: The working model.

In the Drosophila larval brain, Simba1 and Simba2 are required for NSC reactivation by transcriptionally activating Wingless in BBB glia and NSCs. Human homolog ZNF706 might be required for activating WNT signaling in colon cancer cells and HEK293T cells. Created in BioRender. LIN, J. (https://BioRender.com/s1vy3m3).