Fig. 1: Design of ACE2-tropic betacoronavirus therapeutics.
From: Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness
a Phylogenetic tree of SARS-like betacoronaviruses mapped using Nexstrain70. These include betacoronaviruses known to infect humans (e.g., SARS-CoV-2 and SARS-CoV, red and orange) and future pandemic-potential viruses (e.g., betacoronaviruses circulating in pangolins or bats, blue). b Schematic of the ReconnAb-multimer design that links three key components: a pan-betacoronavirus-binding Fab as an anchor (purple); catalytically inactive ACE2 (iACE2) to neutralize (pink); and a multimerization domain (human IgG1 Fc domain, left, or cartilage matrix protein trimerization domain, right) to increase avidity (blue).
