Table 1 Applications of FUTs and FUT inhibitors in clinical settings
From: Structure, function, and implications of fucosyltransferases in health and disease
Trial ID | Study type/phase | Studied parameters | Application | Published results |
|---|---|---|---|---|
NCT05145348 | Observational | Fucosylation level in IgG | Efficacy of SARS-CoV-2 vaccination in DOWN Syndrome patients | |
NCT04067375 | Observational | Fucosylation level in IgG | Identification of pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia | |
NCT01967238 | Early Phase 1 | Fucosylation level in IgG | Efficacy of antiviral vaccinations (influenza, SARS-CoV-2) | |
NCT05394922 | Observational | Fucosylation level in IgG | Correlation between the IgGs’ glycan composition and Lupus | No results published |
NCT01471067 | Phase 1 | Fucosylation level in transplanted cells | FUT6 and FUT7 used to enhance the fucosylation level in transplanted cells to enhance the efficacy of umbilical cord blood transplant (hematologic malignancies) | |
NCT02423915 | Phase 1 | Fucosylation level in transplanted cells | Study of Infusion of Fucosylated Regulatory T Cells to Prevent Graft Versus Host Disease | |
NCT02566655 | Phase 1 | Fucosylation level in transplanted cells | Evaluate the safety of intravenous infusion of fucosylated autologous bone marrow-derived mesenchymal stem cells as a new therapy in patients with osteoporosis | Publication pending |
NCT01983761 | Phase 2 | Fucosylation level in transplanted cells | Enhance the fucosylation level in transplanted cells to enhance the efficacy of umbilical cord blood transplant (hematologic malignancies) | No results published |
NCT06203158 | Observational | Degree of fucosylation in the intestinal epithelium | Study the impact of the degree of fucosylation toward the efficacy of ustekinumab in Crohn’s disease treatment | No results published |
NCT02952989 | Phase 1 | Broad FUT inhibition in combination with PD-1 blockade | Treatment of solid tumors |
