Fig. 6: In vivo potency of PVP-057.
A–C Adult C57BL6/J mice were immunized ID with PBS, 0.5 µg VZV gE alone, or VZV gE admixed with AS01B (1/100th human dose), 10 µg poly(I:C), or PVP-057 at 1, 5, 10, 25, 50, or 100 nmol. Serum samples were collected on Day 42 post-immunization. Anti-VZV gE IgG (A) IgG1 (B), and IgG2c (C) titers were assessed. N = 6 biological replicates per group, except for the PBS group (N = 5). Box plots depict median and interquartile range (IQR), with whiskers extending to minimum and maximum data points. Significance against VZV gE alone is shown with asterisks. One-sided Mann–Whitney U tests were applied for comparisons against VZV gE alone. NSp > 0.05, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Significance against AS01B is shown with hash signs. Two-sided Mann–Whitney U tests were applied for comparisons against AS01B. NSp > 0.05, #p ≤ 0.05, ##p ≤ 0.01, ###p ≤ 0.001. Source data are provided as a Source Data file.
