Fig. 9: PVP-057 enhanced humoral immunogenicity of HHV antigens in a trivalent formulation. | Nature Communications

Fig. 9: PVP-057 enhanced humoral immunogenicity of HHV antigens in a trivalent formulation.

From: Discovery of a small molecule TLR3 agonist adjuvant

Fig. 9

Adult C57BL/6 J mice (N = 6 per group) were immunized intradermally on Day 0 and Day 14 with 0.5 µg VZV gE, 0.5 µg CMV gB, and 0.5 µg HSV gD2 ± PVP-057 (100 nmol). Mice were bled on Day 42, and anti-VZV gE (A), CMV gB (B), and HSV gD2 (C) IgG titers were assessed. N = 6 per group. Box plots depict median and interquartile range (IQR), with whiskers extending to minimum and maximum data points. One-sided Mann–Whitney U tests were applied. NSp > 0.05, *p ≤ 0.05, **p ≤ 0.01. Source data are provided as a Source Data file.

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