Fig. 4: Conserved CD3 surface patches form extensive membrane contacts.
From: The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex
a ND-II model surface colored by sequence conservation (Consurf score) with yellow unmodeled map density shown at two contouring thresholds. Lipid density adjacent to the CD3 ectodomains persists at high threshold (red dashed box). b Top, ND-II model with arrows and eyes indicating viewing directions for surfaces below. Bottom, overviews orienting the zoomed-in views of CD3ϵγ (left) and CD3ϵδ (right) in (c) through (e). Red dashed lines encircle TM surfaces. c Zoomed-in views of the membrane-proximal CD3 heterodimer surfaces. Black triangles highlighting the conserved surface patch at the subunit interface. d Lipid density (yellow) over this conserved patch, visualized at high contouring threshold (as in a, right). e Model surfaces colored by electrostatic potential.
