Fig. 7: DelB/delB mice present with sinus node dysfunction and are susceptible to atrial arrhythmias. | Nature Communications

Fig. 7: DelB/delB mice present with sinus node dysfunction and are susceptible to atrial arrhythmias.

From: PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias

Fig. 7

a Typical examples of ECGs of adult wild-type, delB/+ and delB/delB mice. Arrows point to the first deflection of the P-wave, indicating negative deflections and thus, ectopic activation of the atria in delB/+ and delB/delB mice. b–d Bar graphs showing the direction of the first P wave deflection (Chi-square test), RR interval and HRV (standard deviation of RR interval) in wild-type, delB/+ and delB/delB mice. (Kruskal-Wallis test with Dunn’s multiple comparisons test). e cSNRT120 in wild-type, delB/+ and delB/delB mice; typical examples show cSNRT120 calculated from the last stimulus artifact to the first spontaneous P-wave (Ordinary one-way ANOVA and Tukey’s multiple comparisons test). f Representative examples of ECG traces showing SNRT120. g Incidence (Chi-square, p < 0.05) of induced AA in wild-type, delB/+ and delB/delB mice. h Typical examples of induced AAs. Source data are provided in the Source Data file. ECGs electrocardiograms, HRV heart rate variation, AA atrial arrhythmia, cSNRT120 corrected sinus node recovery time after 120 ms pacing.

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