Fig. 8: Schematic diagram delineates the metabolic and epigenetic mechanisms underlying the ferroptotic propagation during graft kidney IRI. | Nature Communications

Fig. 8: Schematic diagram delineates the metabolic and epigenetic mechanisms underlying the ferroptotic propagation during graft kidney IRI.

From: Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function

Fig. 8

Activation of the lncRNA IGIP-5/miRNA 670-3p/LDHA axis in IRI renal tubular epithelial cells promotes glycolytic reprogramming and lactate shuttling in the graft kidney tissue microenvironment. Lactate shuttle enhances AARS1-mediated NPM1 lactylation in adjacent tubular cells, increasing NPM1 protein stability and reinforcing its transcriptional repression of SLC7A11. The subsequent downregulation of SLC7A11 impairs the cystine/cysteine/GSH metabolism, leading to ferroptotic propagation and DGF. Figure 8 was created in GNU Image Manipulation Program (GIMP). https://www.gimp.org/about.

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