Fig. 3: Substrate scope of fused polyazapolycycles and alcohols. | Nature Communications

Fig. 3: Substrate scope of fused polyazapolycycles and alcohols.

From: Chiral hypervalent iodine catalyzed stereoselective skeletal editing of pyrimidine fused heterocycles

Fig. 3: Substrate scope of fused polyazapolycycles and alcohols.The alternative text for this image may have been generated using AI.

Reaction conditions: 1 or 7 (0.1 mmol, 1.0 equiv), 5c (20 mol%), selectfluor (2.0 equiv), TfOH (3.0 equiv), co-solvent DCM:ROH (v/v 10:1, 4.4 mL) at 30 °C. Yield of isolated product. The ee values were determined by HPLC. The diastereomeric ratio (d.r.) was determined by 1H NMR spectroscopy of the crude reaction mixture. aDCM:MeOH (v/v 3:2, 4.4 mL) was used as solvent. bDCM:ROH (v/v 1:1, 4.4 mL) was used as solvent.

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