Fig. 4: Late-stage functionalization of M1G-dR and its analogues. | Nature Communications

Fig. 4: Late-stage functionalization of M1G-dR and its analogues.

From: Chiral hypervalent iodine catalyzed stereoselective skeletal editing of pyrimidine fused heterocycles

Fig. 4: Late-stage functionalization of M1G-dR and its analogues.The alternative text for this image may have been generated using AI.

Reaction conditions: 9 (0.1 mmol, 1.0 equiv), 5c (20 mol%), selectfluor (2.0 equiv), TfOH (3.0 equiv), co-solvent DCM:MeOH (v/v 1:1, 4.4 mL) at 30 °C. Yield of isolated product. The ee values were determined by HPLC. The diastereomeric ratio (d.r.) was determined by 1H NMR spectroscopy of the crude reaction mixture. aKOH (3.0 equiv) was used as an additive. bThe ee values were determined by HPLC from the hydrolysed product. See Supplementary Information for details.

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