Fig. 1: Significance of aryl C-glycosides, challenges in their synthesis, and our protocol. | Nature Communications

Fig. 1: Significance of aryl C-glycosides, challenges in their synthesis, and our protocol.

From: Direct deoxygenative arylation of saccharides via phosphorus-assisted C−OH bond activation

Fig. 1

a Structure of C-glycosides and representative aryl C-glycosides in drug development. b Common glycosyl donors for accessing aryl C-glycosides. c Synthesis of aryl C-glycosides by activating native C − OH bond. d This work: direct deoxygenative arylation of saccharides via phosphorus-assisted β-scission. Et ethyl, Ar aryl, DHP dihydropyridine, NHC N-heterocyclic carbene, PC photocatalyst, tBu tert-butyl, Ph phenyl.

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