Fig. 4: Metformin pharmacokinetics.
From: Letrozole, abemaciclib and metformin in endometrial cancer: a non-randomized phase 2 trial
A Metformin plasma concentrations in 6 patients receiving combination of metformin + abemaciclib + letrozole on C1D1 (left) and on C1D8 (right); individual patients (dashed lines) and geometric mean and SD (solid circles and error bars). B Metformin steady state trough concentration fold increase from baseline upon initiation of abemaciclib + letrozole dosing. Data are presented as individual patients (dotted lines) and geometric mean values +/- SD (solid lines).
