Fig. 1: Overall structure of the oxoglutarate-GPR99/OXGR1-Gq complex.
From: Molecular insights into ligand recognition and signaling of OXGR1
a Cryo-EM density map of the oxoglutarate-GPR99/OXGR1-Gq complex. GPR99/OXGR1 is shown in cyan, Gαq in light purple, Gβ in light pink, Gγ in wheat yellow, and scFv16 in grey. b 3-D structure of oxoglutarate-GPR99/OXGR1-Gq complex (side view). The structure and EM density of the two oxoglutarate molecules (OG1, OG2) are highlighted in the inset. c, An enlarged view of OG1 and OG2 in the receptor, shown as yellow sticks. Molecular interactions between OG1 and OG2 and GPR99/OXGR1, in side view (d) and extracellular view (e). Polar interactions with key residues of the receptor are shown as red dashed lines.
