Fig. 3: Statistical fine-mapping and functional annotation. | Nature Communications

Fig. 3: Statistical fine-mapping and functional annotation.

From: The genetic architecture of brainstem structures

Fig. 3: Statistical fine-mapping and functional annotation.The alternative text for this image may have been generated using AI.

a The ideogram shows the causal variants (PP > 0.8) identified through statistical fine-mapping of 574 pooled locus-trait associations related to brainstem volumetric traits. We identify 699 unique causal variants, comprising 223 identified solely from EUR analyses, 455 exclusively from cross-ancestry analyses, and 21 from both analyses. b Comparison of the sizes of 95% credible sets for the 476 trait-associated loci identified through statistical fine-mapping for cross-ancestry GWAS (orange) and EUR-GWAS (blue). Two-sided P value is calculated using the Wilcoxon rank-sum test. The sizes of the 95% credible sets are log-transformed and reported as medians and interquartile ranges. c The regional plots show a locus-trait association between 16q22.1 and midbrain absolute volume, demonstrating improved resolution in cross-ancestry fine-mapping. d Categorizing the causal variants (PP > 0.1) from fine-mapping for EUR-GWAS (top) and cross-ancestry GWAS (bottom) based on genomic location and functional consequence. Source data are provided as a Source Data file.

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