Table 1 Damaging PALB2 missense variants associate with increased breast cancer risk

Functional

463/379

1.07

0.93–1.23

0.333

Intermediate

159/109

1.28

1.00–1.64

0.050

Damaging

16/3

4.67

1.36–18.82

0.009

Standards^c

220/38

5.18

3.68–7.38

4.17 × 10⁻²⁸

Functional

59/587

0.99

0.75–1.30

1.000

Intermediate

34/206

1.63

1.12–2.34

0.013

Damaging

3/6

4.94

1.07–20.68

0.043

Standards

71/170

4.14

3.13–5.50

3.7 × 10⁻¹⁹

Functional

245/627

1.10

0.94–1.27

0.228

Intermediate

519/264

1.00

0.86–1.16

1.000

Damaging

51/8

3.25

1.58–7.51

7.83 × 10⁻⁴

Standards

919/65

7.22

5.63–9.38

4.76 × 10⁻⁹³

Functional

245/396

1.09

0.93–1.28

0.285

Intermediate

519/192

0.87

0.73–1.03

0.096

Damaging

51/6

2.73

1.16–6.53

0.013

Standards

919/54

5.47

4.16–7.24

2.68 × 10⁻⁵⁵