Fig. 6: Fragment merging of compounds 3 and 4 results in more than 100-fold improvement in binding affinity. | Nature Communications

Fig. 6: Fragment merging of compounds 3 and 4 results in more than 100-fold improvement in binding affinity.

From: Fragment-based discovery enables direct targeting of the melanoma oncogene MITF

Fig. 6: Fragment merging of compounds 3 and 4 results in more than 100-fold improvement in binding affinity.The alt text for this image may have been generated using AI.

a Crystal structure of MITF(217-296) with compound 6 (PDB ID: 9H7R, gray), overlaid to 3 (in yellow) and 4 (in orange) from previously solved structures (Fig. 5). Protein sidechains are omitted for clarity and the overlapping central phenyl ring is highlighted by a blue circle. b Chemical structure of compounds 3, 4, and 6 (overlapping phenyl rings are marked in blue).

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