Fig. 7: WAT TBX1 and UCP1 levels positively correlate with the fecal P. copri abundance and succinate content in human individuals.
From: Prevotella copri promotes white adipose browning and ameliorates adiposity
a Fecal succinate contents in individuals without obesity (BMI < 28 kg/m2, n = 15) and individuals with obesity (BMI ≥ 28 kg/m2, n = 19). Values are mean ± SEM. Statistical analysis was performed using two-tailed Mann-Whitney U test. b Spearman correlations (two-tailed Spearman’s rank test) between the fecal succinate contents and BMI (n = 34). c, d Two-tailed Spearman correlations between the fecal P. copri abundance and relative UCP1 (c) and TBX1 (d) mRNA level in abdominal subcutaneous WAT (n = 40). e, f Two-tailed Spearman correlations between the fecal succinate contents and relative UCP1 mRNA level (e), TBX1 (f) mRNA level in abdominal subcutaneous WAT (n = 34). g Western blot analysis showing the protein expression of UCP1 and TBX1 in human abdominal subcutaneous WAT from non-obesity (n = 4) and obesity (n = 4) groups. GAPDH serves as a loading control. Source data are provided as a Source Data file.
