Fig. 2: Optimization of reaction parameters. | Nature Communications

Fig. 2: Optimization of reaction parameters.

From: Concise synthesis of chiral tricyclic γ-lactams via synergistic isothiourea/Ir catalyzed asymmetric [3 + 2] annulation

Fig. 2

A Standard conditions. B Impact of ligands. C Impact of reaction condition. D Impact of leaving group of esters. Reaction conditions: 1 (0.2 mmol, 1.0 equiv.), 2 (0.44 mmol, 2.2 equiv.), [Ir(COD)Cl]2 (3.0 mol%), L1 (6.3 mol%), (S)-BTM (10.0 mol%), DIPEA (2.0 equiv.), MeCN (2.0 mL), 70 °C, 10 h. a Isolated yield. b The enantiomeric excess (ee) was determined by HPLC analysis. See Section VI in the SI for complete screening details.

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