Fig. 1: Accumbal CP-AMPARs are necessary for pair bond formation. | Nature Communications

Fig. 1: Accumbal CP-AMPARs are necessary for pair bond formation.

From: Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment

Fig. 1: Accumbal CP-AMPARs are necessary for pair bond formation.

A Timeline for behavioral pharmacology. During cohabitation, two animals interact in a two-chamber apparatus. During the partner preference test (PPT), test animals choose to interact with a partner or stranger animal, tethered on opposite ends of a three-chamber apparatus. B IEM-1460 or vehicle was infused into the NAc. Targeting verified using dye injection. C Effect of infusion on mating bouts, one-sample t(24) = −0.76, p = 0.454. D Vehicle partner vs stranger huddle, paired t(12) = 3.67, p = 0.0032, IEM-1460 paired t(12) = −0.22, p = 0.827. E Partner preference index (partner huddle/total huddle), vehicle vs IEM-1460 t(24) = 3.26, p = 0.003. Data are presented as mean values ± SEM. A, B created partially in BioRender (https://BioRender.com/xiyjkl9).

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