Fig. 3: The molecular and functional characterization of stroma during receptivity establishment.
From: Decrypting spatiotemporal code of human endometrial receptivity
A The average gene expression patterns of stromal subclusters using scRNA-seq (left and middle), with corresponding representative KEGG signaling pathways (right). Data are shown as boxplots where midlines indicate medians, boxes indicate interquartile range, and whiskers indicate minimum/maximum range. ***P < 0.001. B Expression of specific representative genes in stromal subclusters from LH2 to LH12. The color bar represents the normalized expression of genes. C The network diagram showing genes in apoptosis and mitophagy. D Differentially expressed genes between undiffStr, diffStr, and deStr. E UpSet plots visualizing the number of differentially expressed genes among undiffStr, diffStr, and deStr. F Heatmap of expression and regulon activity of putative transcription factors. G Circular heatmap showing the representative transcription factors in different stromal subpopulations. H Spatial visualization of TCF4, CEBPD, and FOS in human endometrium across the LH stages using Stereo-seq (bin10). I UMAP visualization showing the IHH signaling pathway in stromal subclusters. J UMAP visualization showing the mitophagy signaling pathway in stromal subclusters. K UMAP visualization showing stromal trajectory. L Column diagram showing the trajectory score of stromal subclusters.
