Fig. 6: C607-0736 is a broad-spectrum inhibitor of infection caused by pathogenic Vibrio species.
From: Small molecule inhibitor targets OmpV to treat pandemic Vibrio cholerae infection
a, b Evaluation of the colonization ability of three pandemic V. cholerae O1 strains (EL2382, EL2281, and EL1605) (a) and three V. cholerae O139 strains (MO45, 0820, and 0539) (b) in the small intestine of mice administered 10 mg/kg of the C607-0736 (+) or placebo (−) after 22 h (n = 6 mice per group). c, d Evaluation of the colonization ability of three ΔompV pandemic V. cholerae O1 strains (ΔompV-(EL2382), ΔompV-(EL2281), and ΔompV-(EL1605)) (c) and three ΔompV V. cholerae O139 strains (ΔompV-(MO45), ΔompV-(0820), and ΔompV-(0539)) (d) in the small intestine of mice administered 10 mg/kg of the C607-0736(+) or placebo (−) after 22 h (n = 6 mice per group). e–g Evaluation of the colonization ability of ΔompV + (EL2382) and ΔompV + (EL2382-N28A) (e), ΔompV + (MO45) and ΔompV + (MO45-N28A) (f), and ΔompV + (G2871) and ΔompV + (G2871-N28A) (g) in the small intestine of mice administered 10 mg/kg of the C607-0736(+) or placebo (−) after 22 h (n = 6 mice per group). Significance was determined by a two-sided Mann–Whitney U-test (a–g) and is presented as the p value. *p < 0.05, **p < 0.01, ***p < 0.001; ns no significant difference. The data were presented as the mean ± s.d. (a–g). The source data are included in the Source Data file.
