Fig. 4: Multicellular composition and functional evaluation of postimmunotherapy oesophageal squamous cell carcinoma (ESCC).

A Uniform manifold approximation and projection (UMAP) of imaging mass cytometry (IMC) segmentation single-cell clusters. EP epithelial cells, Endo endotheliocytes, SMC smooth muscle cells, FB fibroblasts, Trm cells tissue-resident memory T cells, Tregs regulatory T cells, and M2, M2 macrophages. B,C Scatter plots illustrating the proportions of cellular populations in the pathological complete response (PCR) (n = 10) and non-PCR (n = 10) groups. D Statistical analysis comparing the frequencies of cell populations between the non-PCR (n = 10) and PCR (n = 10) groups. A t test was used to and p value was two sided. Whiskers indicate the range from minimum to maximum values, and the bounds of the boxes represent the 25 and 75th percentiles. The centres denote the medians.