Fig. 2: TMEM65 controls mitochondrial Ca2+ homeostasis.
From: TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis
a, b [Ca2+]mt measurements in HeLa cells expressing a mitochondrially targeted aequorin probe. a Representative [Ca2+]mt traces of control, TMEM65 overexpressing and silenced cells. b Histograms (mean ± s.d.) of histamine-induced [Ca2+]mt peak values. c, d [Ca2+]mt measurements in HeLa cells expressing the mitoGCaMP6 probe. c Representative traces of control, TMEM65 overexpressing and silenced cells. d Histograms (mean ± s.d.) of mitochondrial Ca2+ levels at the indicate time points. Data were analyzed by one-way ANOVA followed by Holm–Sidak’s multiple comparisons test. * indicates p < 0.01. Individual data points, descriptive statistics and exact p values are included in Source Data Table.
