Fig. 4: Grm4 deletion improves α-syn A53T mouse function.
From: mGluR4–NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration
a Diagram illustrating the experimental design for generating and analyzing A53T-Grm4−/− mice. Created in BioRender. Chen, M. (2025) https://BioRender.com/yecxy34. b Graphs show survival rates for A53T-Grm4−/− mice. N=mouse number is shown next to the group label. Gehan–Breslow–Wilcoxon test. p = 0.0020 for A53T vs A53T-Grm4 + /-; p = 0.011 for A53T vs A53T-Grm4−/−. c Graph shows mean ± SEM of grip strength in A53T-Grm4−/− mice. N = mouse number is shown above each bar. One-way ANOVA with Tukey’s post hoc test. ***p < 0.0001 for WT vs A53T, Grm4−/− vs A53T, and A53T vs A53T-Grm4−/−. d Graph shows mean ± SEM of time to turn in the pole test in A53T-Grm4−/− mice. N = mouse number is shown above each bar. One-way ANOVA with Tukey’s post hoc test. ***p < 0.0001 for Grm4−/− vs A53T; **p = 0.0015 for WT vs A53T. e Graphs show the percentage of A53T-Grm4−/− mice remaining in the inverted grid in the inverted wire screen test. N = mouse number is shown next to the group label. Gehan–Breslow–Wilcoxon test. p = 0.83 for A53T vs A53T-Grm4 + /−; p = 0.061 A53T vs A53T-Grm4−/−.
