Fig. 6: Npdc1 loss improves survival and motor function in α-syn A53T mice.
From: mGluR4–NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration
a Diagram illustrating the experimental design for generating and analyzing A53T-Npdc1−/− mice. Created in BioRender. Chen, M. (2025) https://BioRender.com/yecxy34. b Graphs show survival rates for A53T-Npdc1−/− mice. N = mouse number is shown next to the group label. Gehan–Breslow–Wilcoxon test. p = 0.21 for A53T vs A53T-Npdc1 + /-; p = 0.21 for A53T vs A53T-Npdc1−/−. c Graph shows mean ± SEM of grip strength in A53T-Npdc1−/− mice. N = mouse number is shown above each bar. One-way ANOVA with Tukey’s post hoc test. **p = 0.0023 for WT vs A53T; *p = 0.030 for Npdc1−/− vs A53T. d Graph shows mean ± SEM of time to turn in the pole test in A53T-Npdc1−/− mice. N = mouse number is shown above each bar. One-way ANOVA with Tukey’s post hoc test. ***p < 0.0001 for WT vs A53T and Npdc1−/− vs A53T; *p = 0.034 for A53T vs A53T-Npdc1−/−. e Graphs show the percentage of A53T-Npdc1−/− mice remaining in the inverted grid in the wire screen test. N = mouse number is shown next to the group label. Gehan–Breslow–Wilcoxon test. p = 0.75 for A53T vs A53T-Npdc1 + /-; p = 0.054 for A53T vs A53T-Npdc1−/−.
