Fig. 9: Npdc1 and Grm4 deletion alleviates TH-positive neuronal loss in the substantia nigra following striatal a-syn PFF injection.
From: mGluR4–NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration
a Representative images of TH staining in the ipsilateral side of the SNc of in WT, dHET and dKO mice injected with a-syn PFF. Coronal section with dorsal up and midline to left. Scale bar, 500 µm. b Graph shows mean ± SEM of the number of TH positive neurons in the ipsilateral site of the SNc in WT, dHET and dKO mice injected with a-syn PFF. N=mouse number is shown above each bar. One-way ANOVA with Tukey’s test. ***p < 0.0001 for WT-PBS vs WT-PFF, dHET-PBS vs dHET-PFF, dKO-PBS vs dKO-PFF, and for WT-PFF vs dHET-PPF; **p = 0.0030 for WT-PFF vs dKO-PFF.
