Fig. 2: Production variations in cell lineages and population.
a Representative concentration profiles of the single-cell DOD enzyme (top panel) and betaxanthin (bottom panel) for multiple lineages. b Autocorrelation decay of DOD enzyme (top panel, red curve) and betaxanthin (bottom panel, yellow curve) concentration in single cells from experimental measurements and modeling (black curves). c Distribution of single-cell DOD (top panel) and betaxanthin (bottom panel) concentration within the entire population (blue curves). Black vertical lines indicate one standard deviation above and below the population mean. A single low-producing ancestor cell (red arrows) was tracked and the distribution of all its progeny after 7 cell cycles is shown with the red curves. Medium- and high-producing ancestors (green and yellow arrows) and their progenies (curves) are indicated by green and orange colors, respectively. d The dynamics of initial low, medium, and high-producing subpopulations over multiple cell generations. Data points represent biological replicates from two independent experiments. The bar height indicates the mean of the biological replicates. e Cross-correlation between DOD-to-betaxanthin Rpm(τ) (top panel), growth-to-DOD Rμp(τ), and growth rate-to-betaxanthin Rμm(τ) (bottom panel). Source data are provided as a Source Data file.
