Fig. 5: Bioproduction under the control of Megos.
a Megos uses metabolite concentration (m) to promote cell growth rate. b Selection stringency was set by the growth rate dependence on m as described by the threshold hmμ. Five hmμ values were chosen as arrows indicated. c Growth-to-metabolite rate cross-correlation Rμm in open-loop and Megos of different hmμ values. d–f Distributions of single-cell protein (d), metabolite (e) concentrations, and f doubling time in open-loop (black) and Megos of different hmμ values. g Simulated metabolite production under Megos control of different hmμ values. h, i Simulated protein and metabolite titer under Megos control of different hmμ values. Error bar represents standard deviation of 3 different simulations with 300, 400, and 500 cells. The error bar represents the mean of 3 individual simulations performed with 300, 400, and 500 cells. Source data are provided as a Source Data file.
