Fig. 2: Pre- and postsynaptic expression of CUG480 alters synaptic functions at the Drosophila larval NMJ. | Nature Communications

Fig. 2: Pre- and postsynaptic expression of CUG480 alters synaptic functions at the Drosophila larval NMJ.

From: Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy

Fig. 2

a–e Electrophysiology data collected from Drosophila larval NMJs expressing CUG60 or CUG480 presynaptically using C380-Gal4. n = 13,13, where n is the number of analyzed NMJs. f–j Electrophysiology data collected from Drosophila larval NMJs expressing CUG60 or CUG480 postsynaptically using C57-Gal4. n = 14,13, where n is the number of analyzed NMJs. k–o Electrophysiology data collected from Drosophila larval NMJs expressing CUG60 or CUG480 pre+postsynaptically using C380 + C57. n = 10,11, where n is the number of analyzed NMJs. a, f, k mEPSP amplitude. b, g, l EPSP amplitude. c, h, m Quantal content. d, i, n mEPSP frequency. e, j, o Representative electrophysiological traces. Scale bar for EPSP (mEPSP): y = 5 mV (1 mV), x = 50 ms (2 s). Student’s (two-tailed) t-test was used. Histograms depict mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Each larva is defined as a biological replicate, and no more than two NMJs were analyzed per larva.

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