Fig. 6: Simultaneous pre- and postsynaptic overexpression of FasII-C synergistically impairs synaptic functions at the Drosophila larval NMJ. | Nature Communications

Fig. 6: Simultaneous pre- and postsynaptic overexpression of FasII-C synergistically impairs synaptic functions at the Drosophila larval NMJ.

From: Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy

Fig. 6

a–c mEPSP amplitude of Drosophila larval NMJ overexpressing FasII-C using (a) C380, b C57, c C380 + C57. d–f EPSP amplitude of Drosophila larval NMJ overexpressing FasII-C using (d) C380, e C57, f C380 + C57. g–i Quantal content of Drosophila larval NMJ overexpressing FasII-C using (g) C380, h C57, i C380 + C57. j–l mEPSP frequency of Drosophila larval NMJ overexpressing FasII-C using (j) C380, k C57, l C380 + C57. m–o Representative electrophysiological traces. Scale bar for EPSP (mEPSP): y = 5 mV (1 mV), x = 50 ms (2 s). For (a, d, g, j), n = 13, 14, where n is the number of analyzed NMJs. For (b, e, h, k), n = 15,14, where n is the number of analyzed NMJs. For (c, f, i, l), n = 15, 15, where n is the number of analyzed NMJs. Each larva is defined as a biological replicate, and no more than two NMJs were analyzed per larva. Student’s t-test (two-tailed) was used. Histograms depict mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.

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