Fig. 2: Reproductive classes and associations with survival and epigenetic age acceleration (EAA).
From: Epigenetic aging and lifespan reflect reproductive history in the Finnish Twin Cohort
a Probability estimates with 95% confidence intervals (CI) from a latent class model (n = 10,783 parous women). Mortality hazard ratio estimates with 95% CI for each class from a Cox proportional hazards model weighted with class-specific posterior probabilities, and adjusted for left-truncation, historical cohort and relatedness (b n = 14,836 women), and further adjusted for risk factors (alcohol use, smoking, body mass index, education) (c n = 14,836 women). d, e PCGrimAge EAA estimates with 95% CI for each class from a Bolck-Croon-Hagenaars model adjusted for age and relatedness (d n = 1054 women with DNA methylation data), and further adjusted for risk factors (e n = 1054 women with DNA methylation data). b-e The dashed red line indicates the survival analysis reference class (class 3). Source data are provided as a Source Data file.
