Fig. 4: Associations between the number of live births, survival and epigenetic age acceleration (EAA).
From: Epigenetic aging and lifespan reflect reproductive history in the Finnish Twin Cohort
a Mortality hazard ratio estimates with 95% confidence intervals (CI) from a Cox proportional hazards model adjusted for left truncation, historical cohort, relatedness, and risk factors (tobacco and alcohol use, body mass index, education; n = 10,975 women with all covariate data). The red dashed line is drawn for reference at the estimate for women with three live births. b EAA estimates calculated by PCGrimAge with 95% CI from a linear mixed effects model adjusted for relatedness, age and risk factors (n = 855 women with DNA methylation and all covariate data). The red dashed line in the epigenetic models is drawn for reference where the rate of epigenetic aging does not differ from the rate of chronological aging (at 0). Source data are provided as a Source Data file.
