Fig. 3: Origin and evolution of the taxane biosynthetic pathway. | Nature Communications

Fig. 3: Origin and evolution of the taxane biosynthetic pathway.

From: Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis

Fig. 3: Origin and evolution of the taxane biosynthetic pathway.

a The possible taxol biosynthetic pathway. The solid and dotted arrows represent the characterized and unknown reactions, respectively. Red forks indicated the genes that do not exist in P. chienii. The abbreviation is as follows: taxadiene synthase (TS), taxane 5α-hydroxylase (T5OH), taxane 13α-hydroxylase (T13OH), taxadien-5α-ol-O-acetyltransferase (TAT), Taxus cytochrome P450 reductase (TCPR), taxane 2α-hydroxylase (T2OH), taxane 7β-hydroxylase (T7OH), taxane 10β-hydroxylase (T10OH), taxane 9-oxidase (T9OH), taxane oxetanase 1 (TOT1, also named CYP1 or CYP725A55), taxane 2α-O-benzoyl transferase (TBT), 10-deacetyl-baccatin III-10-O-acetyltransferase (DBAT), 13-O-(3-amino-3-phenylpropanoyl) transferase (BAPT), taxane 2’α-hydroxylase (T2’OH), N-debenzoyl-2’-deoxytaxol-N-benzoyltransferase (DBTNBT). b Overview of the known genes involved in taxane biosynthesis. (c) Genome rearrangements between P. chienii and T. wallichiana. Physical and genetic maps of the 142.04–245.71 Mb region of chromosome 9 and 6.56–101.93 Mb region of chromosome 11 were extracted from the P. chienii genome, and the 195.41–486.53 Mb region of chromosome 10 was extracted from the T. wallichiana genome. Source data are provided as a Source Data file.

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